Association between serum trace elements and sleep disturbance in patients with decompensated cirrhosis

Background: Sleep disturbance and trace elements imbalance are common features in patients with decompensated cirrhosis, partially sharing similar mechanistic contributors linking to adverse outcomes. However, there is a paucity of data concerning their relationship. Objectives: To investigate the association between serum levels sleep quality context cirrhosis. Design: Cross-sectional study. Methods: We consecutively enrolled 160 The was determined by Pittsburgh Quality Index (PSQI > 5). Serum [magnesium, calcium, iron, copper (Cu), zinc (Zn), lead, manganese] measured inductively coupled plasma mass spectrometry. Association examined analyzed multiple linear (global PSQI scores) multivariate logistic (dichotomized categories) regression models, respectively. Results: In total, 91 (56.88%) represented PSQI-defined disturbance, characterized female preponderance, lower body index levels, higher Cu (all p < 0.05). Looking into its clinical relevance debilitating conditions, we showed that Cu/Zn ratio (CZr) significantly cirrhosis poor (1.77 versus 1.48, = 0.003). Diagnostic performance analysis indicated CZr 1.62 exhibit better discrimination relative respective Cu. Both (β 0.355, 0.001) (odds 2.364, 0.019) identified as an independent risk factor associated disturbance. Conclusion: Our findings implied presence